Juglanin (C 20H 18O 10, Figure 1), also known as kaempferol 3-O-arabinofuranoside, is a kind of aldose reductase inhibitors. Currently, natural compounds are investigated in the development of different tumor calls in vitro and in vivo. Further, compounds from plants are also of interest for their low cost, multiple targeting properties, relative absence of cytotoxicity and high availability. Presently, compound purified from the natural plants is widely explored for their biological activity, including anti-inflammation and anti-cancer. Thus, finding effective treatment and understanding the molecular mechanism of lung cancer progression are currently essential. But the prognosis for NSCLC is still limited with an overall 5-year survival rate of about 15%. Recently, some progress has been made in clinical and experimental oncology. Of all lung cancer cases, the non-small cell lung cancer (NSCLC) is the most common type, accounting for approximately 85%.
Lung cancer is reported as a leading cause for cancer death worldwide, accompanied with ascending incidence and mortality. Our study demonstrated that juglanin could be a promising candidate against human lung cancer progression. Also, juglanin administration to mouse xenograft models inhibited lung cancer progression. The formation of autophagic vacoules and LC3/autophagy gene7 (ATG7)/Beclin1 (ATG6) over-expression were observed in juglanin-treated cells. ROS inhibitor N-acetyl-l-cysteine (NAC) reversed apoptosis induced by juglanin in cancer cells. Further, juglanin improved ROS and induced autophagy. Additionally, nuclear factor-κB (NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) and mitogen-activated protein kinases (MAPKs) activation were inhibited by juglanin. Anti-apoptotic members Bcl-2 and Bcl-xl were reduced, and pro-apoptotic members Bax and Bad were enhanced in cells and animals receiving juglanin. Juglanin promoted apoptosis in lung cancer cells through increasing Caspase-3 and poly ADP-ribose polymerase (PARP) cleavage, which is regulated by TNF-related apoptosis-inducing ligand/Death receptors (TRAIL/DRs) relied on p53 activation. A significant role of juglanin in suppressing lung cancer growth was observed. In our study, the effects of juglanin on non-small cell lung cancer were investigated. Juglanin administration causes apoptosis and reactive oxygen species (ROS) in different types of cells through regulating various signaling pathways. Juglanin (Jug) is obtained from the crude extract of Polygonum aviculare, exerting suppressive activity against cancer cell progression in vitro and in vivo. Received: JAccepted: AugPublished: September 28, 2017 Keywords: juglanin, lung cancer, apoptosis, ROS, autophagy One of the most notable new features is the integration with the easy-to-use and feature-rich Notepad, where you can easily collect and organize your data, even between all Foxmail clients on desktop and mobile devices Synchronize.Liang Chen 1, Ya-Qiong Xiong 1, Jing Xu 1, Ji-Peng Wang 1, Zi-Li Meng 1 and Yong-Qing Hong 1ġDepartment of Respiration, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, Jiangsu 223300, China
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